Anti-UBE2C Antibody (C-term)
Boster Bio Anti-UBE2C Antibody (C-term) (Catalog # M01491) . Tested in WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Synonyms
Ubiquitin-conjugating enzyme E2 C, 6.3.2.19, UbcH10, Ubiquitin carrier protein C, Ubiquitin-protein ligase C, UBE2C, UBCH10
Gene Name
UBE2C
UniProt
O00762
Host
Mouse
Reactivity
Human
Immunogen
This UBE2C antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 137~172 amino acids from the C-terminal region of human UBE2C.
Clonality
Monoclonal
Clone
Clone: 2001CT211.37.61
Applications
WB
Field of Research
Cell Biology
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
19652 Da
Applications Notes
WB: 1:2000
Prediction Reactivity
Bovine, Monkey, Mouse
Isotype
IgG1, κ
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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