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Anti-TSG101 Antibody

Boster Bio Anti-TSG101 Antibody (Catalog # M01233-1) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) . Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.

Synonyms

Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101

Gene Name

TSG101

UniProt

Q99816

Host

Mouse

Reactivity

Human

Immunogen

This antibody is generated from a mouse immunized with a recombinant protein from human.

Clonality

Monoclonal

Clone

Clone: 1883CT788.47.15.46

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas

Applications

WB

Field of Research

Cancer, Cell Biology, Microbiology, Host-Virus Interaction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

2266041322315426

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

43944 Da

Applications Notes

WB: 1:2000

Subcellular Location

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring. Nucleus. Note=Mainly cytoplasmic. Membrane- associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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