Anti-FHIT Antibody
Boster Bio Anti-FHIT Antibody (Catalog # M01200-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.
Product Specifications
Background
Cleaves P (1) -P (3) -bis (5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P (1) -P (4) -bis (5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P (1) -P (3) -bis (5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca (2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
Synonyms
Bis (5'-adenosyl) -triphosphatase, AP3A hydrolase, AP3Aase, Diadenosine 5',5'''-P1, P3-triphosphate hydrolase, Dinucleosidetriphosphatase, Fragile histidine triad protein, FHIT
Gene Name
FHIT
UniProt
P49789
Host
Mouse
Reactivity
Human
Immunogen
This FHIT antibody is generated from a mouse immunized with a recombinant protein.
Clonality
Monoclonal
Clone
Clone: 1093CT23.1.2
Tissue Specificity
Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung Phospho-FHIT undetected in all tested human tumor cell lines
Applications
WB, Flow Cytometry
Field of Research
Mitochondria
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
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Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
16858 Da
Subcellular Location
Cytoplasm. Mitochondrion. Nucleus
Isotype
IgG1, k
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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