Anti-CALR Antibody (Center)
Boster Bio Anti-CALR Antibody (Center) (Catalog # M00894-1) . Tested in WB application (s) . This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity) .
Synonyms
HGNC:1455
Gene Name
CALR
UniProt
P27797
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
This CALR antibody is generated from a mouse immunized with a recombinant protein from human CALR.
Clonality
Monoclonal
Clone
Clone: 2143CT58.2.1
Applications
WB
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
787624611149926
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
48142 Da
Applications Notes
WB: 1:500
Subcellular Location
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P28491}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3H7}. Cytolytic granule. Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038) . During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity) . In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity) . {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:8418194}
Prediction Reactivity
Human
Isotype
IgG1, κ
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Curated Selection
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