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Anti-HAVCR2 Antibody

Boster Bio Anti-HAVCR2 Antibody (Catalog # M00657-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1) -mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

Synonyms

Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, HAVCR2, TIM3, TIMD3

Gene Name

HAVCR2

UniProt

Q8TDQ0

Host

Mouse

Reactivity

Human

Immunogen

This HAVCR2 antibody is generated from a mouse immunized with a recombinant protein of human HAVCR2.

Clonality

Monoclonal

Clone

Clone: 1827CT151.74.68

Tissue Specificity

Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells

Applications

WB, Flow Cytometry

Field of Research

Immunology, Inflammation, Innate Immunity

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

2482577711823861145560052433774126492563248388571628692024337741235552612232345322383801

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

33394 Da

Subcellular Location

Membrane; Single-pass type I membrane protein. Cell junction. Cell membrane. Note=Localizes to the immunological synapse between CD8+ T-cells and target cells

Isotype

IgG2b, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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