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Anti-VEGFC Antibody

Boster Bio Anti-VEGFC Antibody (Catalog # M00623) . Tested in WB application (s) . This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq].

Synonyms

Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular endothelial growth factor-related protein, VRP, VEGFC

Gene Name

VEGFC

UniProt

P49767

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

This VEGFC monoclonal antibody is generated from mouse immunized with VEGFC recombinant protein.

Clonality

Monoclonal

Clone

Clone: 197CT7.3.4

Tissue Specificity

Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte

Applications

WB

Field of Research

Cancer, Cardiovascular, Developmental Biology, Neuroscience, Signal Transduction, Immunology, Cytokines

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

46883 Da

Applications Notes

WB: 1:1000

Subcellular Location

Secreted.

Isotype

IgG1, K

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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