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Anti-PPARA Antibody

Boster Bio Anti-PPARA Antibody (Catalog # M00600) . Tested in IHC-P, IF, Flow Cytometry, WB application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC) . Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity) . Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.

Synonyms

Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR

Gene Name

PPARA

UniProt

Q07869

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This PPARA antibody is generated from a mouse immunized with a recombination protein from the human region of human PPARA.

Clonality

Monoclonal

Clone

Clone: 1331CT894.186.143

Tissue Specificity

Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758) .

Applications

IHC-P, IF, Flow Cytometry, WB

Field of Research

Cancer, Cardiovascular, Metabolism, TLR Signaling

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC) . Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

52225 Da

Subcellular Location

Nucleus.

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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