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Anti- (Mouse) Suz12 Antibody (Center)

Boster Bio Anti- (Mouse) Suz12 Antibody (Center) (Catalog # M00583-2) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity) . Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.

Synonyms

Polycomb protein Suz12, Suppressor of zeste 12 protein homolog, Suz12, D11Ertd530e, Kiaa0160

Gene Name

Suz12

UniProt

Q80U70

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This mouse Suz12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 381-395 amino acids from the Central region of mouse Suz12.

Clonality

Polyclonal

Tissue Specificity

Expressed in embryonic stem cells.

Applications

WB, IHC-P

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity) . Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

83026 Da

Subcellular Location

Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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