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Anti-AIM2 Antibody

Boster Bio Anti-AIM2 Antibody (Catalog # M00443) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Synonyms

Interferon-inducible protein AIM2, Absent in melanoma 2, AIM2

Gene Name

AIM2

UniProt

O14862

Host

Mouse

Reactivity

Human

Immunogen

This AIM2 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 10-40 region of human AIM2.

Clonality

Monoclonal

Clone

Clone: 812CT9.2.2.1

Tissue Specificity

Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.

Applications

WB

Field of Research

Cancer, Immunology, Inflammation, Innate Immunity

Purification

This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

38954 Da

Applications Notes

WB: 1:1000

Subcellular Location

Cytoplasm. Inflammasome. Nucleus. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles (PubMed:19158679, PubMed:19158676, PubMed:19158675) . Activated inflammasomes can also aggregate in the nucleus in response to DNA damage: AIM2 is recruited to double-strand DNA breaks and mediates activation of the AIM2 inflammasome (By similarity) . {ECO:0000250|UniProtKB:Q91VJ1, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:19158679}

Isotype

IgM

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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