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Anti-RIPK3 Antibody

Boster Bio Anti-RIPK3 Antibody (Catalog # M00202) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Synonyms

Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3

Gene Name

RIPK3

UniProt

Q9Y572

Host

Mouse

Reactivity

Human

Immunogen

This RIPK3 antibody is generated from a mouse immunized with a recombinate protein from the human region of human RIPK3.

Clonality

Monoclonal

Clone

Clone: 2013CT892.86.49

Tissue Specificity

Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney

Applications

WB

Field of Research

Cell Biology, Immunology, Signal Transduction, Mitochondria

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

56887 Da

Applications Notes

WB: 1:1000

Subcellular Location

Cytoplasm, cytosol. Nucleus {ECO:0000250|UniProtKB:Q9QZL0}. Note=Mainly cytoplasmic Present in the nucleus in response to influenza A virus (IAV) infection. {ECO:0000250|UniProtKB:Q9QZL0}

Prediction Reactivity

Human

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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