Anti-PINK1 Antibody

Boster Bio Anti-PINK1 Antibody (Catalog # M00201) . Tested in WB, IHC-P, IF application (s) . This antibody reacts with Human.

Product Specifications

Background

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Synonyms

Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1, PINK1

Gene Name

PINK1

UniProt

Q9BXM7

Host

Mouse

Reactivity

Human

Immunogen

Recombinant PINK1 protein was used to produced this monoclonal antibody.

Clonality

Monoclonal

Clone

Clone: 38CT20.8.5

Tissue Specificity

Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development

Applications

WB, IHC-P, IF

Field of Research

Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Autophagy, Mitochondria

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

62769 Da

Subcellular Location

Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99MQ3}; Single-pass membrane protein. Cytoplasm, cytosol. Note=Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105) . When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282)

Isotype

IgG1

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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