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Anti-CADH1 Antibody

Boster Bio Anti-CADH1 Antibody (Catalog # M00063) . Tested in WB, IHC-P, IF application (s) . This antibody reacts with Human.

Product Specifications

Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.

Synonyms

Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324, E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3, CDH1, CDHE, UVO

Gene Name

CDH1

UniProt

P12830

Host

Mouse

Reactivity

Human

Immunogen

This CADH1 antibody is generated from a mouse immunized with a recombinat protein between 1-392 amino acids from human CADH1.

Clonality

Monoclonal

Clone

Clone: 1579CT577.150.80

Tissue Specificity

Non-neural epithelial tissues.

Applications

WB, IHC-P, IF

Field of Research

Cancer, Developmental Biology, Signal Transduction, Anti-Wnt-Pathway (plus Lgr5) Antibodies

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

1197633311976333

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

97456 Da

Subcellular Location

Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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