Recombinant Rhesus Macaque Interleukin-4
Product Specifications
Background
Interleukin-4 (IL-4) is a pleiotropic cytokine mainly produced by mast cells, activated T cells and bone marrow stromal cells. It has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. Additionally, It enhances both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. The rhesus macaque IL-4 shares about 40 % ~ 45 % a.a. sequence identity with human, mouse, rat IL-4 and they are species-specific in their activities.
Product Name Alternative
BSF-1, Lymphocyte Stimulatory Factor 1
UniProt
P51492
Target
HNCHIALREI IETLNSLTEQ KTLCTKLTIT DILAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE DFLERLKTIM REKYSKCSS
Purification
> 96 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ug of rRhIL-4 as determined by LAL method.
Bioactivity
6
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 14.9 kDa, a single non-glycosylated polypeptide chain containing 129 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 2 x PBS, pH 7.4, 5 % trehalose.
Host or Source
Escherichia coli
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