GRI977143
GRI977143 is a specific LPA2 receptor agonist, with an EC50 of 3.3 μM [1].
Product Specifications
CAS Number
[325850-81-5]
UNSPSC
12352005
Hazard Statement
H302, H372, H410
Target
Caspase; LPL Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gri977143.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC=C1SCCCN(C(C2=CC=CC3=CC=CC4=C23)=O)C4=O
Molecular Formula
C22H17NO4S
Molecular Weight
391.44
Precautions
H302, H372, H410
References & Citations
[1]Gyöngyi N. Kiss, et al. Virtual Screening for LPA2-Specific Agonists Identifies a Nonlipid Compound with Antiapoptotic Actions. Mol Pharmacol. 2012 Dec; 82 (6) : 1162–1173.|[2]Gyöngyi Nagyné Kiss, et al. PHARMACOLOGICAL AND CELLULAR CHARACTERIZATION OF GRI977143, A NOVEL NONLIPID LPA2 RECEPTOR AGONIST IDENTIFIED BY VIRTUAL SCREENING.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LPAR2
Available Sizes
Curated Selection
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