ARP-100

ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM) . ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) [1][2].

Product Specifications

CAS Number

[704888-90-4]

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/arp-100.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NO)CN(S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)OC(C)C

Molecular Formula

C17H20N2O5S

Molecular Weight

364.42

Precautions

H228, H315, H319

References & Citations

[1]Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) . Bioorg Med Chem. 2004 May 1;12 (9) :2441-50.|[2]Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R) - and (S) -N-hydroxy-2- (N-isopropoxybiphenyl-4-ylsulfonamido) -3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14 (12) :4260-76.