ULK-101

ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1].

Product Specifications

CAS Number

[2443816-45-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ULK

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ULK-101.html

Purity

99.96

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

FC1=CC=C(C(C=N2)=CN3C2=C(C4=CSC(C(N[C@@H](C5CC5)C(F)(F)F)=O)=C4)C=N3)C=C1

Molecular Formula

C22H16F4N4OS

Molecular Weight

460.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.