Thalidomide-4-O-C6-NH2 (TFA)
Thalidomide-4-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13 (HY-114421), a degrader of FKBP12F36V and BET[1].
Product Specifications
CAS Number
[1957235-99-2]
UNSPSC
12352005
Hazard Statement
H301, H312, H361
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-4-o-c6-nh2-tfa.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCCN)=O.O=C(O)C(F)(F)F
Molecular Formula
C21H24F3N3O7
Molecular Weight
487.43
Precautions
H301, H312, H361
References & Citations
[1]Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543 (7644) :270-274.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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