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Thalidomide-4-O-C6-NH2 (TFA)

Thalidomide-4-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13 , a degrader of FKBP12F36V and BET[1].

Product Specifications

CAS Number

1957235-99-2

UNSPSC

12352005

Hazard Statement

H301, H312, H361

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-4-o-c6-nh2-tfa.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCCN)=O.O=C(O)C(F)(F)F

Molecular Formula

C21H24F3N3O7

Molecular Weight

487.43

Precautions

H301, H312, H361

References & Citations

[1]Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543 (7644) :270-274.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

Frequently Asked Questions

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