4- (Methylnitrosamino) -1- (3-pyridyl) -1-butanol

4- (Methylnitrosamino) -1- (3-pyridyl) -1-butanol (NNAL), a significant metabolite of the carcinogenic nitrosamine 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone, is linked to the development of lung cancer in smokers.

Product Specifications

CAS Number

[76014-81-8]

Product Name Alternative

NNAL

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-_Methylnitrosamino_-1-_3-pyridyl_-1-butanol.html

Purity

99.94

Smiles

O=NN(CCCC(C1=CC=CN=C1)O)C

Molecular Formula

C10H15N3O2

Molecular Weight

209.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Elucidating the chemical structure of native 1-deoxysphingosine|[2]Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids|[3]Analysis of sphingolipids in extracted human plasma using liquid chromatography electrospray ionization tandem mass spectrometry|[4]Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF) -dependent toxicity via caspase signaling in dopaminergic neurons