AMG 333
AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM.
Product Specifications
CAS Number
1416799-28-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/AMG_333.html
Purity
99.82
Solubility
DMSO : ≥ 125 mg/mL
Smiles
FC1=CC=CN=C1[C@H](C2=CC(F)=C(OC(F)(F)F)C=C2)NC(C3=NC=C(C(O)=O)C=C3)=O
Molecular Formula
C20H12F5N3O4
Molecular Weight
453.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Horne DB, et al. Discovery of TRPM8 Antagonist (S) -6- (((3-Fluoro-4- (trifluoromethoxy) phenyl) (3-fluoropyridin-2-yl) methyl) carbamoyl) nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61 (18) :8186-8201.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
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