P, p'-DDE

P, p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p, p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p, p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p, p'-DDE may be a risk factor for type 2 diabetes in women[1][2].

Product Specifications

CAS Number

[72-55-9]

Product Name Alternative

4,4'-DDE; p, p'-Dichlorodiphenyldichloroethylene

UNSPSC

12352005

Hazard Statement

H301, H351, H372, H410

Target

Androgen Receptor; Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/p-p-dde.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

Cl/C(Cl)=C(C1=CC=C(Cl)C=C1)/C2=CC=C(Cl)C=C2

Molecular Formula

C14H8Cl4

Molecular Weight

318.03

Precautions

H301, H351, H372, H410

References & Citations

[1]Kelce WR, et al. Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375 (6532) :581-585.|[2]Rignell-Hydbom A, et al. Exposure to p, p'-DDE: a risk factor for type 2 diabetes. PLoS One. 2009 Oct 19;4 (10) :e7503.