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Anti-LECT1 CNMD Antibody

Boster Bio Anti-LECT1 CNMD Antibody catalog # A32278. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Leukocyte cell-derived chemotaxin 1 ; Chondromodulin

Gene Name

CNMD

UniProt

O75829

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human LECT1 (NP_008946.1) .

Clonality

Polyclonal

Tissue Specificity

Detected in cartilage and cardiac valves (at protein level) . Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level) . Expression is decreased cardiac valves of patients with valvular heart disease (at protein level) . Weakly expressed in chondrosarcoma.

Applications

WB, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

37102 MW

Gene Name Synonym

Leukocyte cell-derived chemotaxin 1

Subcellular Location

Chondromodulin-1: Secreted, extracellular space, extracellular matrix. Accumulated in the inter- territorial matrix of cartilage.

Protein Name

Leukocyte cell-derived chemotaxin 1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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