Anti-COX6A2 Antibody (Center)
Boster Bio Anti-COX6A2 Antibody (Center) (Catalog # A15662-2) . Tested in IHC-P, WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity.
Synonyms
Cytochrome c oxidase subunit 6A2, mitochondrial, Cytochrome c oxidase polypeptide VIa-heart, COXVIAH, Cytochrome c oxidase subunit VIA-muscle, COX VIa-M, COX6A2, COX6A, COX6AH
Gene Name
COX6A2
UniProt
Q02221
Host
Rabbit
Reactivity
Human
Immunogen
This COX6A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the Central region of human COX6A2.
Clonality
Polyclonal
Tissue Specificity
Expressed specifically in heart and muscle (PubMed:31155743) . Not detected in brain, colon, spleen, kidney, liver, lung and pancreas (PubMed:31155743) .
Applications
IHC-P, WB
Field of Research
Signal Transduction, Mitochondria
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
31155743
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
10815 Da
Subcellular Location
Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07471}; Single-pass membrane protein {ECO:0000250|UniProtKB:P07471}
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Curated Selection
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