Anti-R Cbwd1 Antibody (C-term)
Boster Bio Anti-R Cbwd1 Antibody (C-term) (Catalog # A15555) . Tested in WB application (s) . This antibody reacts with Rat.
Product Specifications
Synonyms
COBW domain-containing protein 1, Cobalamin synthase W domain-containing protein 1, Cbwd1
Gene Name
ZNG1
UniProt
Q99MB4
Host
Rabbit
Reactivity
Rat
Immunogen
This Rat Cbwd1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-351 amino acids from the C-terminal region of rat Cbwd1.
Clonality
Polyclonal
Applications
WB
Field of Research
Cell Biology, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
43931 Da
Applications Notes
WB: 1:1000
Subcellular Location
Nucleus {ECO:0000250|UniProtKB:Q8VEH6}.
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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