Anti-IA-6 INSM2 Antibody
Boster Bio Anti-IA-6 INSM2 Antibody (Catalog # A14973) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription.
Synonyms
IA6, IA-6, mlt1, IA6, Nbla106, Insulinoma-associated protein 2, Zinc finger protein IA-6
Gene Name
INSM2
UniProt
Q96T92
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
IA-6 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human IA-6. The immunogen is located within amino acids 340 - 390 of IA-6.
Clonality
Polyclonal
Tissue Specificity
Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level) . Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level) .
Applications
ELISA, WB
Field of Research
Cancer
Purification
IA-6 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. .
Storage Conditions
IA-6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
59491 MW
Gene Name Synonym
Insulinoma-associated 2
Subcellular Location
Cytoplasm . Nucleus .
Protein Name
Insulinoma-associated 2
Isotype
IgG
Contents
IA-6 Antibody is supplied in PBS containing 0.02% sodium azide.
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