Anti-Acetyl-NF-E4 (K43) Antibody
Boster Bio Anti-Acetyl-NF-E4 (K43) Antibody catalog # A14260. Tested in WB, ELISA, IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Transcription factor NF-E4; NFE4
Gene Name
NFE4
UniProt
Q86UQ8
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized acetyl-peptide derived from the human NF-E4 around the acetylation site of K43.
Tissue Specificity
Specifically expressed in fetal liver, cord blood and bone marrow. Also expressed in the K562 and HEL cell lines, which constitutively express the fetal globin genes. .
Applications
WB, ELISA, IHC
Purification
Immunogen affinity purified
Sensitivity
>5000 cells
Concentration
1 mg/mL
Form
Liquid
Function
Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR) . The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
19019 MW
Gene Name Synonym
Transcription factor NF-E4
Subcellular Location
Nucleus .
Isotype
IgG
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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