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Anti-GPR75 Antibody

Boster Bio Anti-GPR75 Antibody catalog # A13384. Tested in WB, IF, ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Probable G-protein coupled receptor 75; GPR75

Gene Name

GPR75

UniProt

O95800

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human GPR75. AA range:381-430

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level) . .

Applications

WB, IF, ELISA

Purification

The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.

Concentration

1 mg/mL

Form

Liquid

Function

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

59359 MW

Gene Name Synonym

Probable G-protein coupled receptor 75

Subcellular Location

Cell membrane; Multi-pass membrane protein .

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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