Anti-DNAJB8 Antibody
Boster Bio Anti-DNAJB8 Antibody catalog # A12844-1. Tested in WB, ELISA. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
DNAJB8, a member of the DNAJ/HSP40 family of proteins, plays a crucial role in regulating chaperone HSP70 activity. It is known for its ability to suppress the aggregation of polyglutamine proteins through its C-terminal tail. Furthermore, DNAJB8 has been shown to inhibit TP53 through ubiquitin degradation in human colon cancer by directly interacting and upregulating MDR1, leading to increased oxaliplatin resistance. High levels of DNAJB8 in both colon tissues and serum are correlated with worse overall survival of colon cancer patients, suggesting that DNAJB8 level in serum sEV may serve as a potential biomarker for colon cancer and a promising therapeutic target for oxaliplatin-resistant cancer.
Gene Name
DNAJB8
UniProt
Q8NHS0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human DNAJB8 recombinant protein (Position: N3-M229) .
Clonality
Polyclonal
Applications
WB, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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