Anti-TMEM55B/PIP4P1 Antibody
Boster Bio Anti-TMEM55B/PIP4P1 Antibody catalog # A12499. Tested in WB, IP, ELISA. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
TMEM55B is also named as C14orf9 and PIP4P1. TMEM55B is originally identified as phosphatidylinositol-4,5-P24-phosphatases (PtdIns-4,5-P24-phosphatases) that catalyze dephosphorylation of PtdIns-4,5-P2 to PtdIns-5-P. The transmembrane protein TMEM55B is involved in the perinuclear clustering of lysosomes upon starvation. TMEM55B expression is upregulated upon starvation via TFEB and TFE3 activation, and loss of TMEM55B diminishes starvation-induced lysosomal clustering. TMEM55B can bind to the dynein adaptor JIP4, promoting dynein-dynactin-dependent lysosomal trafficking to the perinuclear region. TMEM55B is also suggested to contribute to lysosomal homeostasis and mTORC1 activation via the V-ATPase assembly (PMID: 33537719) .
Gene Name
PIP4P1
UniProt
Q86T03
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human TMEM55B/PIP4P1 recombinant protein (Position: G17-P80) .
Clonality
Polyclonal
Applications
WB, IP, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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