Anti-PTCHD2 DISP3 Antibody

PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

PTCHD2 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human PTCHD2. The immunogen is located within amino acids 1240 - 1290 of PTCHD2.

Plays a role in neuronal proliferation and differentiation (PubMed:25281927) . Plays a role in the accumulation of cellular cholesterol (By similarity) . Involved in intracellular lipid droplet formation (PubMed:25281927) . May contribute to cholesterol homeostasis in neuronal cells (By similarity) .

PTCHD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.