Anti-CLEC6A Antibody
Boster Bio Anti-CLEC6A Antibody catalog # A11863. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
C-type lectin domain family 6 member A ; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2
Gene Name
CLEC6A
UniProt
Q6EIG7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human CLEC6A
Clonality
Polyclonal
Tissue Specificity
Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Binds high-mannose carbohydrates in a Ca (2+) -dependent manner (PubMed:28652405) . Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
23998 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
C-type lectin domain family 6 member A
Subcellular Location
Membrane ; Single-pass type II membrane protein .
Protein Name
C-type lectin domain family 6 member A
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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