Anti-PRTFDC1 Antibody

Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.

PRTFDC1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human PRTFDC1. The immunogen is located within amino acids 90 - 140 of PRTFDC1.

Has low, barely detectable phosphoribosyltransferase activity (in vitro) . Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP) . Is not expected to contribute to purine metabolism or GMP salvage.

PRTFDC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.