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Anti-ZNRF2 Antibody

Boster Bio Anti-ZNRF2 Antibody (Catalog# A11505) . Tested in IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

ZNRF2; RNF202; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; Zinc/RING finger protein 2

Gene Name

ZNRF2

UniProt

Q8NHG8

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A peptide derived from human ZNRF2. Immunogen sequence location: 161-210

Clonality

Polyclonal

Tissue Specificity

Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.

Applications

IHC, ICC, IF, ELISA

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ring Finger E3 Ligase, Ubiquitin E3 Enzymes

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

24115 MW

Gene Name Synonym

E3 ubiquitin-protein ligase ZNRF2

Subcellular Location

Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Present in presynaptic plasma membranes in neurons.

Isotype

Rabbit IgG

Contents

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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