Anti-RBM15B Antibody
Boster Bio Anti-RBM15B Antibody catalog # A11484. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Putative RNA-binding protein 15B ; One-twenty two protein 3
Gene Name
RBM15B
UniProt
Q8NDT2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human RBM15B (NP_037418.3) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518) . Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518) . Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518) . Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518) . Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689) . Inhibits pre-mRNA splicing (PubMed:21044963) . Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
97205 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Putative RNA-binding protein 15B
Subcellular Location
Nucleus, nucleoplasm
Protein Name
Putative RNA-binding protein 15B
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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