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Anti-GNB4 Antibody (Center)

Boster Bio Anti-GNB4 Antibody (Center) (Catalog # A11086) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

Synonyms

Guanine nucleotide-binding protein subunit beta-4, Transducin beta chain 4, GNB4

Gene Name

GNB4

UniProt

Q9HAV0

Host

Rabbit

Reactivity

Human

Immunogen

This GNB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human GNB4.

Clonality

Polyclonal

Tissue Specificity

Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves

Applications

WB

Field of Research

Cancer, Metabolism, Signal Transduction, Anti-Wnt-Pathway (plus Lgr5) Antibodies, Chemokine signaling

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

37567 Da

Applications Notes

WB: 1:1000

Prediction Reactivity

Bovine, Hamster, Zebrafish, Drosophila, Mouse, Rat, Xenopus

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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