Anti-CCRN4L NOCT Antibody
Boster Bio Anti-CCRN4L NOCT Antibody catalog # A10951. Tested in WB applications. This antibody reacts with Human, Rat.
Product Specifications
Synonyms
Nocturnin
Gene Name
NOCT
UniProt
Q9UK39
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A synthetic peptide corresponding to residues in Human CCRN4L
Clonality
Polyclonal
Tissue Specificity
Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly (A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity) . .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
48196 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Nocturnin
Subcellular Location
Cytoplasm . Nucleus . Cytoplasm, perinuclear region .
Protein Name
Nocturnin
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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