Anti-SHC-transforming protein 4 SHC4 Antibody
Boster Bio Anti-SHC-transforming protein 4 SHC4 Antibody catalog # A10841. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
SHC-transforming protein 4; Rai-like protein; RaLP; SHC-transforming protein D; hShcD; Src homology 2 domain-containing-transforming protein C4; SH2 domain protein C4; SHC4; SHCD; UNQ6438/PRO21364
Gene Name
SHC4
UniProt
Q6S5L8
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human SHC4 (NP_976224.3) .
Clonality
Polyclonal
Tissue Specificity
Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
68785 MW
Gene Name Synonym
SHC-transforming protein 4
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane. Colocalized with MUSK at the neuromuscular junction. .
Protein Name
SHC-transforming protein 4
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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