Anti-CRISP2 Antibody
Boster Bio Anti-CRISP2 Antibody (Catalog # A10681) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Product Specifications
Background
The cysteine-rich secretory proteins (CRISP) family is a group of four proteins that are strongly expressed in the male reproductive tract and have been implicated in having roles in male fertility. CRISP2, also known as TPX1, has been implicated in the adhesion between spermatids and Sertoli cells, and with CRISP1, is thought to be involved in sperm-egg fusion. CRISP2 has been shown to regulate the Ca2+ influx through ryanodine receptors (RYR) and may influence the acrosome reaction or sperm motility. CRISP2 has also been shown to bind to the mitogen-activated protein kinase kinase kinase 11 (MAP3K11) and localizes to the developing acrosome, suggesting this CRISP2-MAP3K11 complex may have a role in acrosome development.
Synonyms
CT36, TPX1, TSP1, GAPDL5, CRISP-2, Cysteine-rich secretory protein 2, Testis-specific protein TPX-1
Gene Name
CRISP2
UniProt
P16562
Host
Rabbit
Reactivity
Human
Immunogen
CRISP2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human CRISP2. The immunogen is located within the first 50 amino acids of CRISP2.
Clonality
Polyclonal
Tissue Specificity
Testis and epididymis.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Signal Transduction
Purification
CRISP2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. .
Storage Conditions
CRISP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
27259 MW
Gene Name Synonym
Cysteine-rich secretory protein 2
Subcellular Location
Secreted .
Protein Name
Cysteine-rich secretory protein 2
Isotype
IgG
Contents
CRISP2 Antibody is supplied in PBS containing 0.02% sodium azide.
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