Anti-SIGLEC6 Antibody
Boster Bio Anti-SIGLEC6 Antibody catalog # A10598-3. Tested in IHC, ELISA applications. This antibody reacts with Human.
Product Specifications
Background
Siglec-6, originally identified on trophoblast cells of the placenta, is highly and consistently expressed on MCs from both mucosal and non-mucosal sites. Siglec-6 consists of 3 extracellular immunoglobulin (Ig) domains and 2 intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs), closely resembling the molecular structure of Siglec-3 (CD33) (PMID: 34289026) . Siglec-6 was recruited to placental expression during human evolution, presumably to interact with sialylated ligands for specific negative signaling functions and/or to regulate leptin availability (PMID: 17580316) . Siglec-6 is an immunoreceptor tyrosine-based inhibitory motif (ITIM) -bearing receptor selectively expressed by mast cells, making it a promising target for therapeutic intervention (PMID: 35406705) .
Gene Name
SIGLEC6
UniProt
O43699
Host
Rabbit
Reactivity
Human
Immunogen
E.coli-derived human SIGLEC6 recombinant protein (Position: R18-D197) .
Clonality
Polyclonal
Applications
IHC, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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