Anti-ZCCHC8 Antibody
Boster Bio Anti-ZCCHC8 Antibody catalog # A10566-1. Tested in WB, IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
The eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors (RBM7, ZCCHC8 and hMTR4) interact to form the nuclear exosome targeting (NEXT) complex, which directs a subset of non-coding RNAs for exosomal degradation. ZCCHC8 acts as a scaffold, mediating the interaction between RBM7 and MTR4. NEXT is involved in exosome-mediated surveillance and decay of noncoding RNAs, such as enhancer RNAs (eRNAs) and aberrant 3′-extended transcripts from small nuclear RNA (snRNA), telomerase RNA, and replication-dependent histone genes. NEXT is an important node in regulating nuclear exosome activities and takes part in several biological processes, including DNA damage response, stress response, and viral ribogenesis . ZCCHC8 also has a robust interaction with YTHDC1 (PMID: 28984244) .
Synonyms
ZCCHC8
Gene Name
ZCCHC8
UniProt
Q6NZY4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
E.coli-derived human ZCCHC8 recombinant protein (Position: V357-A705) .
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Gene Name Synonym
Zinc finger CCHC-type containing 8
Protein Name
Zinc finger CCHC domain-containing protein 8
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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