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Anti-beta-HSD7 HSD3B7 Antibody

Boster Bio Anti-beta-HSD7 HSD3B7 Antibody catalog # A10025. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

3 beta-hydroxysteroid dehydrogenase type 7;3 beta-hydroxysteroid dehydrogenase type VII;3-beta-HSD VII;3-beta-hydroxy-Delta (5) -C27 steroid oxidoreductase; C (27) 3-beta-HSD;1.1.1.-; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase;1.1.1.181; HSD3B7

Gene Name

HSD3B7

UniProt

Q9H2F3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human HSD3B7. AA range:121-170

Clonality

Polyclonal

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C (19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870) . Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7- alpha,25-OHC) : 7-alpha,25-OHC acts as a ligand for the G protein- coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

41016 MW

Gene Name Synonym

3 beta-hydroxysteroid dehydrogenase type 7

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Name

3 beta-hydroxysteroid dehydrogenase type 7

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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