Anti-H2AFY2 Antibody (Center)

Boster Bio Anti-H2AFY2 Antibody (Center) (Catalog # A09931) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Synonyms

Core histone macro-H2A2, Histone macroH2A2, mH2A2, H2AFY2, MACROH2A2

Gene Name

MACROH2A2

UniProt

Q9P0M6

Host

Rabbit

Reactivity

Human

Immunogen

This H2AFY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-169 amino acids from the Central region of human H2AFY2.

Clonality

Polyclonal

Applications

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

40058 Da

Applications Notes

WB: 1:1000

Subcellular Location

Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin (PubMed:11331621, PubMed:11262398) and in senescence- associated heterochromatin (PubMed:15621527)