Anti-PPP2R5B Antibody (C-term)
Boster Bio Anti-PPP2R5B Antibody (C-term) (Catalog # A09894-1) . Tested in IF, WB application (s) . This antibody reacts with Human.
Product Specifications
Background
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308' and 'Ser-373' residues.
Synonyms
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform, PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit isoform R5-beta, PPP2R5B
Gene Name
PPP2R5B
UniProt
Q15173
Host
Rabbit
Reactivity
Human
Immunogen
This PPP2R5B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 466-500 amino acids from the C-terminal region of human PPP2R5B.
Clonality
Polyclonal
Tissue Specificity
Highest expression in brain.
Applications
IF, WB
Field of Research
Neuroscience, Signal Transduction, Anti-Wnt-Pathway (plus Lgr5) Antibodies
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
57393 Da
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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