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Anti-RFWD3 Antibody

Boster Bio Anti-RFWD3 Antibody catalog # A09738-2. Tested in WB, IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

RFWD3, also named as RNF201, is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. (PMID: 20173098) From BLAST result, this antibody is specific to RFWD3. 45kd and 55kd maybe splicesome of RFWD3.

Synonyms

RNF201; RING finger protein 201; RING finger and WD repeat domain-containing protein 3; EC:2.3.2.27; E3 ubiquitin-protein ligase RFWD3

Gene Name

RFWD3

UniProt

Q6PCD5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human RFWD3 recombinant protein (Position: G429-K772) .

Clonality

Polyclonal

Applications

WB, IHC, ICC, IF, ELISA

Purification

Immunogen affinity purified.

Concentration

500 μg/mL

Form

Liquid

Storage Conditions

12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.

Gene Name Synonym

Ring finger and WD repeat domain 3

Protein Name

E3 ubiquitin-protein ligase RFWD3

Contents

500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.

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