Anti-ASAH3L ACER2 Antibody
Boster Bio Anti-ASAH3L ACER2 Antibody catalog # A09706. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Monkey, Mouse.
Product Specifications
Synonyms
Alkaline ceramidase 2; AlkCDase 2; Alkaline CDase 2; haCER2;3.5.1.23; Acylsphingosine deacylase 3-like; N-acylsphingosine amidohydrolase 3-like; ACER2; ASAH3L; PP11646
Gene Name
ACER2
UniProt
Q5QJU3
Host
Rabbit
Reactivity
Human, Monkey, Mouse
Immunogen
Synthesized peptide derived from ASAH3L . at AA range: 50-130
Clonality
Polyclonal
Tissue Specificity
Highly expressed in placenta. .
Applications
WB, IHC, IF, ELISA
Purification
Immunogen affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C (18:1) -, C (20:1) -, C (20:4) -ceramide > D-erythro-C (16:0) -, C (18:0), C (20:0) - ceramide > D-erythro-C (24:1) -ceramide > D-erythro-C (12:0) - ceramide, D-erythro-C (14:0) -ceramides > D-erythro-C (24:0) -ceramide > D-erythro-C (6:0) -ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
31309 MW
Gene Name Synonym
Alkaline ceramidase 2
Subcellular Location
Golgi apparatus membrane ; Multi- pass membrane protein .
Isotype
IgG
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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