Anti-3'-5' RNA helicase YTHDC2 YTHDC2 Antibody
Boster Bio Anti-3'-5' RNA helicase YTHDC2 YTHDC2 Antibody catalog # A09692. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
3'-5' RNA helicase YTHDC2 ;3.6.4.13
Gene Name
YTHDC2
UniProt
Q9H6S0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human YTHDC2 (NP_073739.3) .
Clonality
Polyclonal
Tissue Specificity
Expressed in testis (PubMed:29087293) . Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321) . Specifically recognizes and binds N6-methyladenosine (m6A) - containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321) . Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity) . Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321) . Required for both spermatogenesis and oogenesis (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
160248 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
3'-5' RNA helicase YTHDC2
Subcellular Location
Cytoplasm
Protein Name
3'-5' RNA helicase YTHDC2
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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