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Anti-IL-1RL2 Antibody

Boster Bio Anti-IL-1RL2 Antibody (Catalog # A09203) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1) . Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2) . IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3) .

Synonyms

IL-36R, IL1RRP2, IL-1Rrp2, IL1R-rp2, Interleukin-1 receptor-like 2, IL-36 receptor, IL-36R

Gene Name

IL1RL2

UniProt

Q9HB29

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

IL-1RL2 antibody is human, mouse and rat reactive. At least three isoforms of IL-1RL2 are known to exist; this antibody will detect all three isoforms. IL-1RL2 antibody is predicted to not cross-react with IL-1R or IL-1RL1.

Immunogen

IL-1RL2 antibody was raised against a 16 amino acid peptide near the center of human IL-1RL2. The immunogen is located within amino acids 260 - 310 of IL-1RL2.

Clonality

Polyclonal

Tissue Specificity

Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte- derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology

Purification

IL-1RL2 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for interleukin-36 (IL36A, IL36B and IL36G) . After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity) . The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway.

Storage Conditions

IL-1RL2 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

65405 MW

Gene Name Synonym

Interleukin 1 receptor-like 2

Subcellular Location

Membrane; Single-pass type I membrane protein

Protein Name

Interleukin 1 receptor-like 2

Isotype

IgG

Contents

IL-1RL2 antibody is supplied in PBS containing 0.02% sodium azide.

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