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Anti-Ephexin-1 NGEF Antibody

Boster Bio Anti-Ephexin-1 NGEF Antibody catalog # A08935. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Ephexin-1; Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor; NGEF

Gene Name

NGEF

UniProt

Q8N5V2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human NGEF (NP_062824.2) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.

Applications

WB, IHC, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

82496 MW

Gene Name Synonym

Ephexin-1

Subcellular Location

Cytoplasm . Membrane . Cell projection, growth cone . Associated with membranes. Localizes to axonal growth cones (By similarity) . .

Protein Name

Ephexin-1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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