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Anti-LMCD1 Antibody (C-term)

Boster Bio Anti-LMCD1 Antibody (C-term) (Catalog # A08888) . Tested in WB application (s) . This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity) . Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Synonyms

LIM and cysteine-rich domains protein 1, Dyxin, LMCD1

Gene Name

LMCD1

UniProt

Q9NZU5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This LMCD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 316-350 amino acids from the C-terminal region of human LMCD1.

Clonality

Polyclonal

Tissue Specificity

Expressed in the heart (at protein level) . Expressed in many tissues with highest abundance in skeletal muscle

Applications

WB

Field of Research

Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6- mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity) . Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

40833 Da

Applications Notes

WB: 1:1000

Subcellular Location

Cytoplasm. Nucleus. Note=May shuttle between the cytoplasm and the nucleus.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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