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Anti-HSD17B8 Antibody

Boster Bio Anti-HSD17B8 Antibody catalog # A08741. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Estradiol 17-beta-dehydrogenase 8;1.1.1.62

Gene Name

HSD17B8

UniProt

Q92506

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human HSD17B8 (NP_055049.1) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.

Applications

WB, IHC, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863) . The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508) . Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

26974 MW

Gene Name Synonym

Estradiol 17-beta-dehydrogenase 8

Subcellular Location

Mitochondrion matrix

Protein Name

Estradiol 17-beta-dehydrogenase 8

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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