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Anti-NAC-1 NACC1 Monoclonal Antibody

Boster Bio Anti-NAC-1 NACC1 Monoclonal Antibody catalog # A08675. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human.

Product Specifications

Synonyms

Nucleus accumbens-associated protein 1; NAC-1; BTB/POZ domain-containing protein 14B; NACC1; BTBD14B, NAC1

Gene Name

NACC1

UniProt

Q96RE7

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of human NAC-1 expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 6H2

Tissue Specificity

Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. .

Applications

WB, IHC, IF, ELISA

Purification

Ascitic fluid

Concentration

1 mg/mL

Form

Liquid

Function

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

57258 MW

Gene Name Synonym

Nucleus accumbens-associated protein 1

Subcellular Location

Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation. .

Contents

Ascitic fluid containing 0.03% sodium azide.

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